2. Anti-infection
  3. SARS-CoV
  4. Dihydrotanshinone I

Dihydrotanshinone I  (Synonyms: 二氢丹参酮 I)

目录号: HY-N0360 纯度: 99.57%
COA 产品使用指南

摩尔计算器

Dihydrotanshinone I 是从丹参中分离到的天然产物，广泛用于心血管疾病的研究。Dihydrotanshinone I 可抑制 MERS-CoV。

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Dihydrotanshinone I Chemical Structure

Dihydrotanshinone I Chemical Structure

CAS No. : 87205-99-0

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规格 价格 是否有货 数量
5 mg ￥569
In-stock
10 mg ￥1000
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25 mg ￥2100
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50 mg ￥3038
In-stock
100 mg ￥4253
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500 mg   询价  

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Customer Review

Other Forms of Dihydrotanshinone I:

Dihydrotanshinone I 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Dihydrotanshinone I is a natural compound extracted from Salvia miltiorrhiza Bunge which has been widely used for treating cardiovascular diseases. Dihydrotanshinone I exhibits entry-blocking effect for MERS-CoV.

体外研究
(In Vitro)

在脂多糖 (LPS) 刺激的人脐静脉内皮细胞 (HUVEC) 中，Dihydrotanshinone I (10 nM) 降低凝集素样 ox-LDL 受体 1 (LOX-1) 和 NADPH 氧化酶 4 (NOX4) 的表达、活性氧 (ROS) 产生、NF-κB 核转位、ox-LDL 内吞和单核细胞粘附[1]。
Dihydrotanshinone I 在 HCT116 细胞中诱导 caspase 依赖性细胞凋亡。Dihydrotanshinone I 诱导浓度和 ROS 依赖性半胱天冬酶激活。Z-VAD-fmk 完全阻止了 Dihydrotanshinone I 诱导的细胞凋亡。Dihydrotanshinone I 诱导的细胞凋亡被 Z-LEHD-fmk 的预处理显著抑制，但仅被 Z-IETD-fmk 部分抑制。Caspase-2 敲低可显著增加二氢丹参酮 I 诱导的细胞凋亡[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Dihydrotanshinone I 相关抗体:
体内研究
(In Vivo)

DHT (10 和 25 mg/kg) 显著减弱 ApoE-/- 小鼠的动脉粥样硬化斑块形成、改变血清脂质谱、降低氧化应激并缩小坏死核心区域。DHT显著抑制主动脉中LOX-1、NOX4和NF-κB的表达增强[1]。
Dihydrotanshinone I (1，2，4 mg/kg) 处理可以改善心肌缺血再灌注大鼠的心功能，减少梗死面积，改善心肌酶谱和组织病理学异常的变化，减少20-HETE的产生，调节凋亡相关蛋白[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

278.30

Formula

C18H14O3
CAS 号
性状

固体

颜色

Brown to red

中文名称

二氢丹参酮 I
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 1 year
-20°C 6 months
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 2 mg/mL (7.19 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.5932 mL 17.9662 mL 35.9324 mL
5 mM 0.7186 mL 3.5932 mL 7.1865 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 1 year; -20°C, 6 months。-80°C储存时，请在1年内使用， -20°C储存时，请在6个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.57%

COA (295 KB) HNMR (191 KB) LCMS (104 KB)

产品使用指南 (1538 KB)
参考文献
Kinase Assay
[3]

Cells are treated with various concentrations of Dihydrotanshinone I (3.13-20 µM) for 48 h. For the activity assay, Ac-DEVD-AMC (1 µg/µL), Ac-IETD-AMC (1 µg/µL) or Ac-LEDH-AMC (1 µg/µL) and cell lysate are added into Protease Assay Buffer in 96-well plate. Reaction mixtures with lysis buffer are used as negative controls. Cells treated with DMSO (0.1%) are treated as vehicle control. The reaction mixtures are incubated for 1 h at 37°C. The AMC liberated from the substrates is measured using spectrofluorometer of Victor 2 plate reader with an excitation wavelength of 380 nm and an emission wavelength of 430 nm.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration
[1]

Male ApoE-/- mice (6-8 weeks old) on C57BL/6J background and age-matched wild-type C57BL/6J controls housed in SPF-grade animal facilities with a 12 h light/dark cycle, at 23°C (±2°C). Starting from 6 weeks, the mice are fed with a HCD (54.35% raw grain, 20% lard, 0.15% cholesterol, 15% sucrose, 0.5% Sodium Cholate, 10% yolk powder) for 12 weeks. All ApoE-/- mice are dosed daily via intragastric gavage with 10 and 25 mg/kg Dihydrotanshinone I dissolved in 0.5% CMC-Na or administered 0.5% CMC-Na alone (vehicle control) (n=8 per group).

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Dihydrotanshinone I 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 1 year; -20°C, 6 months。-80°C储存时，请在1年内使用， -20°C储存时，请在6个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5932 mL 17.9662 mL 35.9324 mL 89.8311 mL
5 mM 0.7186 mL 3.5932 mL 7.1865 mL 17.9662 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dihydrotanshinone I87205-99-0二氢丹参酮 ISARS-CoVSARS coronavirusInhibitorinhibitorinhibit

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